Age-Related Macular Degeneration Clinical Trials

23 studies are recruiting for age-related macular degeneration in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

   Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) ca…

   Stage

   Phase 2

   Ages

   50 and older

   Site

   Research Network Arizona / Retina Macula Institute of Arizona, Scottsdale, Arizona

   Locations

   124 in total

   Run by

   EyeBiotech Ltd.

   See if you can join NCT07440225 on ClinicalTrials.gov

2. The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

   Oral disulfiram (Antabuse®) has been shown to improve image-forming vision in animal models with retinal degeneration due to its ability to decrease Retinoic Acid synthesis and consequently reduce hyperactivity in the inner retina. The investigator will aim to evaluate the impact of oral disulfiram…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06319872 on ClinicalTrials.gov

3. National Eye Institute Biorepository for Retinal Diseases

   Background: - To understand diseases of the retina and the eye, information is needed about people with and without such diseases. Researchers want to study these people and follow them over time. They also want to study body tissues and blood to understand the nature of eye disease. Studying genes…

   Stage

   Not phased

   Ages

   2 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Eye Institute (NEI)

   See if you can join NCT01496625 on ClinicalTrials.gov

4. A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

   Age-related macular degeneration (AMD) is an eye disease which causes people to lose their sharp central vision over time. Aging damages the macula, which is in the middle of the retina - the light-sensitive part at the back of the eye. There are 2 types of AMD - wet AMD and dry AMD. The advanced s…

   Stage

   Phase 1

   Ages

   50 and older

   Site

   Jules Stein Eye Institute, Los Angeles, California

   Locations

   20 in total

   Run by

   Astellas Institute for Regenerative Medicine

   See if you can join NCT03178149 on ClinicalTrials.gov

5. Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration

   The goal of this clinical trial is to characterize the safety and effectiveness of the i-Lumen AMD transpalpebral microcurrent device and therapy in patients with intermediate to advanced nonexudative AMD. Participants will: * Undergo an initial loading regimen, followed by 7 maintenance over the c…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Retina Consultants San Diego, Poway, California

   Locations

   13 in total

   Run by

   i-Lumen Scientific AUS PTY LTD

   See if you can join NCT06662162 on ClinicalTrials.gov

6. Phase 1 Study of C.001 in Retinal Degeneration

   This is a first-in-human Phase 1 study evaluating the safety and tolerability of C.001 in patients with retinal diseases involving degeneration of the retinal pigment epithelium. Participants will receive a single administration of C.001 delivered by subretinal injection. The study will evaluate th…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Retina Vision Consultants, Beverly Hills, California

   Locations

   3 in total

   Run by

   Cellio Therapeutics Inc

   See if you can join NCT07594236 on ClinicalTrials.gov

7. AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

   The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which …

   Stage

   Not phased

   Ages

   50 to 89

   Site

   Duke Eye Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06619405 on ClinicalTrials.gov

8. A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

   Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) ca…

   Stage

   Phase 2

   Ages

   50 and older

   Site

   Associated Retina Consultants - Gilbert, Gilbert, Arizona

   Locations

   71 in total

   Run by

   EyeBiotech Ltd.

   See if you can join NCT07496567 on ClinicalTrials.gov

9. Effects of Goji vs. Fiber on Macular Degeneration

   The goal of this project is to conduct a clinical trial in 60 participants ranging from age 65-95 who are at risk for age-related macular degeneration (AMD). The study will evaluate the effects of 14g of goji berry intake or an equivalent amount and type of fiber, five days a week for six months, o…

   Stage

   Not phased

   Ages

   65 to 95

   Site

   UC Davis Eye Center, Tschannen Eye Institute, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT06237127 on ClinicalTrials.gov

10. Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

    Age-related macular degeneration (AMD) is the abnormal growth of new blood vessels in the light-sensitive tissue at the back of the eye called the retina. Geographic Atrophy (GA) is an advanced form of dry AMD. The purpose of this study is to assess the adverse events and how intravitreal ABBV-6628…

    Stage

    Phase 1

    Ages

    50 and older

    Site

    Retina Partners Midwest, P.C. /ID# 262172, Carmel, Indiana

    Locations

    5 in total

    Run by

    AbbVie

    See if you can join NCT07160179 on ClinicalTrials.gov

11. Visual Remapping to Aid Reading With Field Loss

    Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.

    Stage

    Not phased

    Ages

    16 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT03848663 on ClinicalTrials.gov

12. Stem Cell Ophthalmology Treatment Study II

    This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.

    Stage

    Not phased

    Ages

    18 and older

    Site

    MD Stem Cells, Westport, Connecticut

    Locations

    4 in total

    Run by

    MD Stem Cells

    See if you can join NCT03011541 on ClinicalTrials.gov

13. Village-Integrated Eye Worker Trial II

    The vast majority of blindness is avoidable. The World Health Organization (WHO) estimates that 80% of cases of visual impairment could be prevented or reversed with early diagnosis and treatment. The leading causes of visual impairment are cataract and refractive error, followed by glaucoma, age-r…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT03752840 on ClinicalTrials.gov

14. The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma

    The goal of this clinical trial is to learn if education about additional task lighting, enhanced contrast, enlarged print instructions, smart apps and organizational strategies will improve medication management skills. The main questions it aims to answer are: Does additional task lighting, enhan…

    Stage

    EARLY_Phase 1

    Ages

    50 to 100

    Site

    MCPHS 10 Lincoln Square, Worcester, Massachusetts

    Run by

    MCPHS University

    See if you can join NCT06593405 on ClinicalTrials.gov

15. Adaptive Optics Imaging of Outer Retinal Diseases

    The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomar…

    Stage

    Not phased

    Ages

    21 and older

    Site

    NIH Clinical Center, Bethesda, Maryland

    Locations

    2 in total

    Run by

    Food and Drug Administration (FDA)

    See if you can join NCT05355415 on ClinicalTrials.gov

16. High Resolution Retinal Imaging

    Studying the morphology and function of the normal and diseased retina in vivo is needed for advancing the detection, diagnosis, and treatment of retinal disease. This protocol uses an adaptive optics scanning laser ophthalmoscope (AOSLO) to image the normal and diseased retina with individual cell…

    Stage

    Not phased

    Ages

    7 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT01866371 on ClinicalTrials.gov

17. Strategies for Improving Linkage-to-Care After Eye Disease Screening

    The goal of this randomized, parallel-group, controlled trial is to compare methods of improving linkage-to-care for participants in the Village Integrated Eye Worker II (VIEW II) trial who are referred to the eye hospital following eye disease screening. Participants who are referred to the hospit…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06943599 on ClinicalTrials.gov

18. Central micrOperimetry and Radial OCT Evaluation in Geographic Atrophy (CORE-GA): a Prospective Pilot Study

    This study is being conducted to assess two imaging methods-central microperimetry and radial OCT (Optical Coherence Tomography)-in patients with Geographic Atrophy (GA) or those who are at risk of developing this condition. The study team is trying to determine whether these methods can provide mo…

    Stage

    Not phased

    Ages

    55 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07556406 on ClinicalTrials.gov

19. Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID)

    1000 participants from up to 25 international locations who are at least 50 years old with either healthy eyes or a diagnosis of Age-Related Macular Degeneration (AMD) will be consented to provide images of their eyes for a new dataset. This dataset is an important step in developing an Artificial …

    Stage

    Not phased

    Ages

    50 and older

    Site

    Bergstrom Eye Research LLC, Fargo, North Dakota

    Locations

    14 in total

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06924021 on ClinicalTrials.gov

20. Progression of Early Atrophic Lesions

    Early atrophic age-related macular degeneration (AMD) represents an important time window in the course of so far untreatable atrophic AMD, as patients typically experience only some degree of visual dysfunction, while being at significant risk for marked further loss of vision. To allow the precis…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT05959005 on ClinicalTrials.gov

21. Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD

    interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT

    Stage

    Phase 2

    Ages

    50 to 85

    Site

    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts

    Run by

    Massachusetts Eye and Ear Infirmary

    See if you can join NCT04735263 on ClinicalTrials.gov

22. Lutein, Zeaxathin, and Fish Oil Supplementation

    The goal of this clinical trial is to learn the impact of lutein, zeaxanthin, and fish oil (LZF) supplementation in healthy adults. The main question it aims to answer is: Will supplementation with LZF improve macular pigment optical density (MPOD), cognitive performance and bone mass compared to c…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Gilchrist Building, College Station, Texas

    Run by

    Texas A&M University

    See if you can join NCT06489873 on ClinicalTrials.gov

23. Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD

    The objective of this study is to determine the safety and effectiveness of the smaller incision, new generation (SING), implantable miniature telescope (IMT) in patients with moderate-severe central vision loss due to late-stage age-related macular degeneration (AMD).

    Stage

    Not phased

    Ages

    65 and older

    Site

    Loma Linda University, Loma Linda, California

    Locations

    10 in total

    Run by

    VisionCare, Inc.

    See if you can join NCT05438732 on ClinicalTrials.gov