Acute Ischemic Stroke Clinical Trials

18 studies are recruiting for acute ischemic stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke

   Extensive research is being conducted in search of neuroprotective agents for possible use in the acute phase of stroke and agents that can be used for neurorepair in later stages of stroke. Several trials have been conducted and are in progress using different pharmacological agents, but none of t…

   Stage

   Phase 3

   Ages

   18 to 80

   Site

   The University of Arizona - College of Medicine, Tucson, Arizona

   Locations

   54 in total

   Run by

   Pharmazz, Inc.

   See if you can join NCT05691244 on ClinicalTrials.gov

2. Safety and Efficacy of J147 in Acute Ischemic Stroke

   The goal of this clinical trial is to find out if the drug J147 improves outcomes for persons who have had an ischemic stroke. It also will learn about the safety of J147 when given by injection to stroke patients. Researchers will compare the outcomes of those who receive J147 after therapy to cle…

   Stage

   Phase 2

   Ages

   18 to 90

   Site

   Javon Bea Hospital, Rockford, Illinois

   Locations

   5 in total

   Run by

   Abrexa Pharmaceuticals, Inc.

   See if you can join NCT07430917 on ClinicalTrials.gov

3. A Study of TAK-755 in Adults With Acute Ischemic Stroke

   Acute ischemic stroke (AIS) is a medical emergency that happens because of a sudden stop of blood flow to a part of the brain. This happens when a blood clot forms within the vessel (known as thrombotic occlusion) or a clot originating from somewhere else blocks a blood vessel (known as embolic occ…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   HonorHealth Neurology, Scottsdale, Arizona

   Locations

   60 in total

   Run by

   Takeda

   See if you can join NCT07392450 on ClinicalTrials.gov

4. FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions

   The objective of this study is to collect safety and effectiveness data on the Penumbra System reperfusion catheters in participants with isolated primary non-dominant and distal M2 occlusions who undergo endovascular mechanical thrombectomy (EVT). Additionally, this study aims to observe character…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Fort Sanders Regional Medical Center, Knoxville, Tennessee

   Run by

   Penumbra Inc.

   See if you can join NCT07749170 on ClinicalTrials.gov

5. REal-world Clinical evAulation of Medtronic NeurOVascular Products for Acute Ischemic Stroke (RECANOVA Registry)

   Post-Market Registry

   Stage

   Not phased

   Ages

   18 and older

   Site

   McLaren Flint Hospital, Flint, Michigan

   Locations

   3 in total

   Run by

   Medtronic Neurovascular Clinical Affairs

   See if you can join NCT07599904 on ClinicalTrials.gov

6. RIsE Stroke Mobility Study

   This study is designed to better understand how patients with severe stroke move during their hospital stay. It will track their activity using a small wearable device (activPAL) along with standard mobility information already collected in clinical care. The goal is to learn what typical movement …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Wake Forest University Health Sciences, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT07638462 on ClinicalTrials.gov

7. Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well

   SELECT LATE trial aims to evaluate if addition of endovascular thrombectomy to medical management in patients presenting with acute ischemic stroke and a proximal large vessel occlusion in the anterior circulation between 24 and 72 hours of stroke onset results in achieving better functional outcom…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   University of Chicago, Chicago, Illinois

   Locations

   6 in total

   Run by

   Amrou Sarraj

   See if you can join NCT07115940 on ClinicalTrials.gov

8. The Pivotal Study of RapidPulseTM Aspiration System

   The goal of this clinical trials is to demonstrate the safety and effectiveness for the RapidPulseTM Aspiration System in patients experiencing acute ischemic stroke within 8 hours of symptom onset or last seen normal. Subjects will undergo mechanical thrombectomy (a procedure to remove a clot in t…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Providence Saint John's Medical Foundation, Torrance, California

   Locations

   30 in total

   Run by

   RapidPulse, Inc

   See if you can join NCT06029491 on ClinicalTrials.gov

9. Emergent Large Vessel Occlusion Endovascular Rescue Therapy With Underlying Intracranial Stenosis

   The study objective is to establish the safety and efficacy of endovascular adjunct stenting for patients undergoing mechanical thrombectomy (MT) that are found to have residual stenosis (70-99%) following attempted clot retrieval with either aspiration catheters or stent retrievers, per device ins…

   Stage

   Phase 3

   Ages

   18 to 80

   Site

   ProMedica Toledo Hospital, Toledo, Ohio

   Run by

   ProMedica Health System

   See if you can join NCT07356284 on ClinicalTrials.gov

10. Blood Pressure Variability and Ischemic Stroke Outcome

    The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are: 1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale-New Haven Hospital, New Haven, Connecticut

    Locations

    3 in total

    Run by

    Yale University

    See if you can join NCT05756257 on ClinicalTrials.gov

11. Study of BB-031 in Acute Ischemic Stroke Patients (RAISE)

    The purpose of this study is to evaluate the safety and tolerability of ascending doses (Part A) and selected doses (Part B) of BB-031 in acute ischemic stroke patients presenting within 24 hours of stroke onset. Participants will be randomized to receive one dose of either the investigational drug…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    HonorHealth Bob Bove Neuroscience Institute, Scottsdale, Arizona

    Locations

    25 in total

    Run by

    Basking Biosciences, Inc.

    See if you can join NCT06226805 on ClinicalTrials.gov

12. Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke

    Many patients with acute ischemic stroke are ineligible for currently available standard treatments (clot-busting medication, also known as intravenous thrombolytic or mechanical removal of a clot), and many are non-responders, resulting in a low rate of excellent outcomes, which necessitates the d…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California- Los Angeles (UCLA), Los Angeles, California

    Locations

    3 in total

    Run by

    University of California, Los Angeles

    See if you can join NCT06440707 on ClinicalTrials.gov

13. Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke

    This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted managem…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Barnes-Jewish Hospital, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07404852 on ClinicalTrials.gov

14. Optimizing Reperfusion to Improve Outcomes and Neurologic Function

    The goal of this study is to evaluate the safety and efficacy of JX10 versus placebo in participants with Acute Ischemic Stroke (AIS) who present for care within 4.5 to 24 hours. The main question the study aims to answer are: 1. JX10 improves functional outcomes as measured by the modified Rankin …

    Stage

    Phase 2

    Ages

    18 to 90

    Site

    Corxel Investigational Site, Long Beach, California

    Locations

    83 in total

    Run by

    Corxel Pharmaceuticals

    See if you can join NCT06990867 on ClinicalTrials.gov

15. Brain, Blood And Clot or Tissue Registry And Collaboration

    This is a prospective open enrollment biorepository to collect and evaluate blood and tissue collected during cerebrovascular procedures, which will then be used for the purposes of identifying biological markers, inflammatory cell infiltrates, and biological states in stroke and other cerebrovascu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kentucky Deparment of Neurosurgery, UK Chandler Hospital, Lexington, Kentucky

    Run by

    Justin Fraser

    See if you can join NCT03153683 on ClinicalTrials.gov

16. SUMMIT RISE Study of Acute Ischemic Stroke Patients

    SUMMIT RISE Study of Acute Ischemic Stroke Patients

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Route 92 Medical, Inc., West Jordan, Utah

    Run by

    Route 92 Medical, Inc.

    See if you can join NCT07436156 on ClinicalTrials.gov

17. Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

    The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circul…

    Stage

    Phase 3

    Ages

    18 to 79

    Site

    Mobile Infirmary Medical Center, Mobile, Alabama

    Locations

    51 in total

    Run by

    Mercy Health Ohio

    See if you can join NCT05611242 on ClinicalTrials.gov

18. Hyperbaric Oxygen Therapy in Acute Ischemic Stroke Ischemic Stroke Recovery (Pro00061930)

    This study will critically examine the feasibility, safety and efficacy of HBOT during inpatient rehabilitation (IPR) after acute ischemic stroke measured by non-disruption of 3 hours of daily therapy, frequency of neurological deterioration or complications (seizure, hemorrhage, brain edema), and …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Touro Infirmary New Orleans, New Orleans, Louisiana

    Run by

    LCMC Health

    See if you can join NCT06148285 on ClinicalTrials.gov